Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model

Figure 6

Decreased BDNF staining in hippocampus of recurrent seizure rats 6 months after seizure induction by CTZ. (a-b) Pictures showing BDNF positive cells (arrow indicated) in left (a) and right (b) hippocampus from rats 6 months after either DMSO (top) or CTZ (bottom) treatment. (c-d) Group data showing significant decreases of the BDNF staining cells in CA1, CA3, and DG area of the hippocampus from rats 6 months after either DMSO (𝑛=3) or CTZ (𝑛=3) treatment. **𝑃<0.01, ***𝑃<0.001, compared to the DMSO control group. Scale bar in (a) and (b): 200 μm.

(a)  

(b)

(c)

(d)