Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model

Figure 7

Decreased TrkB staining in hippocampus of recurrent seizure rats induced by CTZ. (a-b) Pictures showing TrkB positive cells (arrow indicated) in left (a) and right (b) hippocampus from rats 6 months after either DMSO (top) or CTZ (bottom) treatment. (c-d) Group data showing significant decreases of the TrkB staining cells in CA1, CA3, and DG area of the hippocampus from rats 6 months after either DMSO (𝑛=3) or CTZ (𝑛=3) treatment. *𝑃<0.05, **𝑃<0.01, compared to the DMSO control group. Scale bar in (a) and (b): 200 μm.

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