Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats

Figure 3

Effects of Aβ _1–42 on the spontaneous firing of EC neurons. (a) Representative traces show the changes of firing activity of EC neurons after application of vehicle (upper), Aβ _1–42 (middle), and scrambled Aβ _1–42 (lower). Drugs were applied during the bar. The two traces in upper panel show firing patterns before (A) and after (B) the application of drugs. The upper right panel of each group displays the waveform of the recorded neuron across each protocol. No obvious change in the spike shape parameters was observed. (b) Time-response curves of the firing rate changes in EC neurons after administration of vehicle, Aβ _1–42, and scrambled Aβ _1–42 (, versus baseline values (500 s before injection)). (c) Bar graph summarizing effects of vehicle, Aβ _1–42, and scrambled Aβ _1–42 on the firing rate of EC neurons at 1000 s after local injection (, NS, no significant difference versus vehicle group). (d) Correlation between the firing rate at 1000 s after injection and the basal firing values in EC neurons. Aβ _1–42 tended to enhance the low-rate spontaneous discharge more strongly.

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