Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats

Figure 5

GAS pretreatment inhibited Aβ _1–42-induced increase in firing rate of EC neurons in a concentration-dependent manner. (a) Representative traces show that pretreatment with 10 mM GAS (lower) prevented the Aβ _1–42-induced increase in firing rate of EC neurons, whereas saline (upper) had no obvious effect. (b) Time-response curves of Aβ _1–42-induced changes of firing rate in EC neurons, pretreated with saline or 10 mM GAS (, versus baseline values (500 s before saline or GAS injection)). (c) Concentration-dependent inhibitory effects of GAS on Aβ _1–42-induced firing rate changes (^#, ^## versus saline alone group, ^&, ^&& versus saline plus Aβ _1–42 group, , ).

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