Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development
Figure 11
Distributions and Kruskal-Wallis-ANOVAs of neuronal response latency and duration in NT and T animals. (a) Distribution of response latencies (given in % observations binned into 5 ms bins) before (blue) and after (red) trauma in vehicle treated (open symbols) and EGb 761-treated animals (solid symbols) with the median values and interquartile range given above. Additionally, the statistics of the Mann-Whitney -tests (corrected for multiple comparisons)—testing of median and interquartile range—and the Kolmogorov-Smirnov tests for the testing of the whole distributions against each other are plotted. Note that in both tests only the two pre- and two postdatasets between the groups are significantly different from each other while pre- versus posttrauma data are equal in both animal groups. (b) Median neuronal response latency (in ms ± interquartile range) tested by Kruskal-Wallis-ANOVAs (-statistics) and multiple comparisons between the subgroups (, , ) separated in nontinnitus and tinnitus perceiving animals treated with vehicle or EGb 761 before and after trauma. (c) Median neuronal response duration (in ms ± interquartile range) was analyzed as above.
