Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF
Figure 1
Inclined plane test was employed to evaluate motor behavior recovery or rats that received a sham operation (Sham) or a photothrombotic injury at the low thoracic level of the spinal cord and were treated with a local injection of phosphate buffered saline (Saline) or pigmented epithelial derived factor (PEDF). Values were expressed as a percentage of the Sham group. The tests were performed daily until the third day and then weekly until the sixth week after surgery and were grouped into three periods (1–3 days; 1–3 weeks; 4–6 weeks). Two-way ANOVA showed differences on motor recovery of animals regarding time of post injury, treatment, and the interaction between them, as described in the text. Bonferroni posttest pointed out differences between groups [() when Saline or PEDF groups differ from Sham; ###()] when the PEDF group differs from Saline. Means ± s.e.m., .
