Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo

Figure 1

Body weight and water intake of rats given access to drinking water (𝑛=18) or drinking water containing fluoxetine (0.2 mg/mL; 𝑛=20) during a 4-week treatment period. (a) Fluoxetine treatment significantly reduced body weight gain during the treatment period. ANOVA results: effect of time, 𝐹(4,144)=370.8, 𝑃<0.0001; effect of group, 𝐹(1,36)=5.8, 𝑃=0.02; interaction, 𝐹(4,144)=13.8, 𝑃<0.0001; * indicates significant (𝑃<0.05) simple effects tests. (b) Fluoxetine also reduced fluid intake relative to the control (water) condition during the entire treatment period. ANOVA results: effect of time, 𝐹(13,286)=2.3, 𝑃=0.006; effect of group, 𝐹(1,22)=43.9, 𝑃<0.0001; interaction, 𝐹(13,286)=0.9, 𝑃=0.6. Note that statistics for fluid intake are limited to 𝑛=12 for both groups since some of the water bottles used did not permit accurate measurement of fluid consumption.

(a)

(b)