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Neural Plasticity
Volume 2014, Article ID 584314, 12 pages
Research Article

Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors

1Department of Medical Chemistry, University of Szeged, Szeged 6726, Hungary
2Biological Research Center—Biochemistry, Hungarian Academy of Sciences, Temesvari Körút 32, Szeged 6726, Hungary

Received 13 June 2014; Revised 5 August 2014; Accepted 17 August 2014; Published 3 September 2014

Academic Editor: Lucas Pozzo-Miller

Copyright © 2014 Edina Varga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Edina Varga, Gabor Juhasz, Zsolt Bozso, Botond Penke, Livia Fueloep, and Viktor Szegedi, “Amyloid-beta(1-42) Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse,” Journal Of Alzheimers Disease, vol. 45, no. 2, pp. 449–456, 2015. View at Publisher · View at Google Scholar
  • Kevin N. Hascup, and Erin R. Hascup, “Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor,” Journal of Alzheimer's Disease, vol. 53, no. 1, pp. 337–347, 2016. View at Publisher · View at Google Scholar
  • Ming Lei, Huixin Xu, Zhangyuan Li, Zemin Wang, Tiernan T. O'Malley, Dainan Zhang, Dominic M. Walsh, Pingyi Xu, Dennis J. Selkoe, and Shaomin Li, “Soluble A beta oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance,” Neurobiology Of Disease, vol. 85, pp. 111–121, 2016. View at Publisher · View at Google Scholar
  • Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson, and Mireille Albrieux, “TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide,” Molecular Neurodegeneration, vol. 12, no. 1, 2017. View at Publisher · View at Google Scholar
  • Irene Sánchez-Rodríguez, Sara Temprano-Carazo, Alberto Nájera, Souhail Djebari, Javier Yajeya, Agnès Gruart, José M. Delgado-García, Lydia Jiménez-Díaz, and Juan D. Navarro-López, “Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, and Sam Gandy, “CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons,” Acta Neuropathologica Communications, vol. 5, no. 1, 2017. View at Publisher · View at Google Scholar
  • Yang Yang, Wei-gang Ji, Zhi-ru Zhu, Yu-ling Wu, Zhi-yang Zhang, and Shao-chen Qu, “Rhynchophylline suppresses soluble Aβ 1-42 -induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors,” Neuropharmacology, 2018. View at Publisher · View at Google Scholar