Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors

Figure 1

Exemplar recordings and the timeline of the experiments. Both evoked fEPSPs and spiking activity recording electrodes were located in the CA1 region of mouse hippocampal slice. The fEPSPs were recorded from the stratum radiatum (a) and the spontaneous spiking was recorded from the stratum pyramidale (b). Both fEPSPs and spiking activity were recorded from the same slice. Data were considered as multiunit activity. (c) shows the timeline of the recordings. The initial spiking activity (recorded at 0 h) was considered as 100% in each slice.

(a)

(b)

(c)