Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors

Figure 2

AMPA receptors mediate fEPSPs but not spontaneous activity. Blocking AMPARs abolished fEPSPs (a). Bar graphs show the average of the fEPSPs amplitudes of the 25–30 min period after treatment. CNQX induced a complete reduction of evoked fEPSPs (, ) (b); however the spiking activity was not affected (c). Inset at the right panel shows representative fEPSPs before (grey) and after (black) treatment and representative spike trains. Error bars show SEM; .