Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors

Figure 6

Abeta(1-42) induces hyperexcitation via NR2B. Abeta(1-42) induced increased spiking activity (untreated versus Abeta(1-42): 1 h: ; 2 h: ; 2.5 h: ; Mann-Whitney test). Ifenprodil did not affect spontaneous activity but prevented the elevated spiking rate caused by Abeta(1-42) (Abeta(1-42) versus ifenprodil + Abeta(1-42) 2.5 h, ; Mann-Whitney test). Upper panel shows exemplar units from the respective recordings, while bottom panel illustrates representative spike trains. Error bars represent SEM; ; ; .