Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Figure 6

Involvement of various K⁺ channels in SNP-induced membrane hyperpolarization. ((a), (b)) Changes in membrane potential evoked by SNP (1 mM) were significantly inhibited by CTX and TEA, BK channel blockers. (c) Membrane hyperpolarization was not significantly inhibited by the presence of apamin, a SK channel blocker. (d) Membrane hyperpolarization was inhibited by application of glibenclamide, a K_ATP channel blocker. (e) Bar graphs show the membrane potential changes elicited by application of various K⁺ channel blockers. *Values are significantly different from the control (SNP), based on independent 𝑡-test analysis (𝑃<0.05), **𝑃<0.01, ***𝑃<0.001. Mean ± SEM.

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