Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Figure 7

Involvement of a nonspecific cation channel in the membrane depolarization induced by SNP. (a) Membrane depolarization evoked by SNP (10 μM) was not inhibited by the presence of 1 mM Cs⁺. (b) Depolarization evoked by SNP was significantly inhibited by La³⁺, a nonspecific cation channel blocker. (c) Bar graphs show the membrane potential changes induced by pretreatment with Cs⁺ and La³⁺. **Values are significantly different from the control (SNP), based on independent 𝑡-test analysis (𝑃<0.01). Mean ± SEM.

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