Salicylate-Induced Auditory Perceptual Disorders and Plastic Changes in Nonclassical Auditory Centers in Rats

Figure 7

The effects of SS injection on auditory responses of the LA. (a) An example of LFP to noise burst at 100 dB SPL (black) showing an increase after SS injection (red). (b) Mean RMSs of LFP (𝑛=15) in a time window of 100 ms as a function of stimulation level, showing enhancement at high stimulation levels ≥60 dB SPL but reduction at low-stimulation levels <60 dB SPL. (c) Example of PSTHs in response to tones at 1.0 kHz (left) and 8.0 kHz (right) before and after SS injection showing greater increase after SS injection at the high-frequency; (d) SS-induced changes (%) of mean discharge rate in a time window of 100 ms showing SS-induced increase in the frequency range of 8–27.7 kHz. Stimulation: 50 ms noise or tone bursts; treatment: SS (250 mg/kg, i.p.). The vertical bars are SEs. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.

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