Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu

Figure 3

Relationship of adolescent pGLP-1 to adolescent waist circumference as a function of early life stress. For abdominal circumference (cm), a markedly inverse correlation with pGLP-1 was noted in VFD subjects but the same correlation in non-VFD subjects was nonsignificantly positive, leading to a significant “” difference between rearing groups. GLM revealed a significant rearing group abdominal circumference interaction in the prediction of pGLP-1 [; ]. When adjusting for abdominal circumference, pGLP-1 concentrations (pmol/L) were significantly increased in VFD versus non-VFD subjects [VFD mean (SE) = 85.00 (5.45) versus non-VFD mean (SE) = 45.68 (8.61); ; ].