Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu

Figure 4

Relationship of adolescent pGLP-1 to adult body mass as a function of early life stress. Adolescent pGLP-1 was inversely associated with adult body mass in VFD but positively associated with adult body mass in non-VFD, leading to a significant difference in the “” value. GLM revealed a significant rearing group adult body mass interaction in the prediction of pGLP-1 [; ] whereas, when adjusting for adult body mass, pGLP-1 concentrations were significantly increased in VFD versus non-VFD subjects [VFD mean (SE) = 85.00 (11.13) versus non-VFD mean (SE) = 45.68 (17.60); ; ].