Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu

Figure 5

Schema of predicted and paradoxical associations of adolescent metabolic markers in the prediction of adult neurogenesis. Green lines indicate correlations that are observed to occur in the predicted direction whereas red lines are predictions that are observed to be opposite to the predicted direction. The significant Kendall coefficient of concordance for multiple dependent variables determined by the Friedman ANOVA (see text under results) raises the possibility of a complex, ostensibly paradoxical physiological metabolic pattern, which sets the stage for future neurogenesis, whereby glucose and lipids provide vital metabolic substrates in the maintenance of the relatively high levels of neurogenesis observed in relatively low BMI macaques.