Neural Plasticity

Research Article

Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu

Table 1

Predictors of neurogenesis rates (square root doublecortin counts) and rearing effects with post hoc Spearman correlation verification.


	Rearing effect	SQRT DCN	Sp

Adolescent incretin (df = 1,11)
pGLP-1			.72

Adolescent morphometrics (df = 1,11)
BMI			−.88
Circ			−.73
SAD			−.65
Crl			−.31
Body mass			−.74
Age			−.26

Adolescent glucose metabolism (df = 1,8)
Insulin (pmol/L)			.69
Glucose (ng/mL)			−.22
IGR			.67
HOMA			.66

Adolescent lipid profile (mg/dL) (df = 1,11)
Triglyc.			.16
HDL			.32
LDL			.71
CHOL			.67
VLDL			.36

Adult (df = 1,11)
Age (years)			−.32
Weight (kg)			−.43

Significant effects bolded. SQRT doublecortin = square root of dentate gyrus immature neurons (mm³), Sp = Spearman’s rho correlation, pGLP-1 = plasma glucagon-like peptide-1 (pmol/L), Crl = crown-rump length (cm), BMI = body mass index (kg/m²), Circ = waist circumference (cm), SAD = sagittal abdominal diameter (cm), IGR = insulin/glucose ratio, HOMA = homeostatic model of assessment, and Triglyc. = triglycerides.