Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury

Table 2

Brain regions significantly activated/deactivated during fMRI with the modified Conners Continuous Performance Test (CCPT) task (average and load conditions) in healthy controls and patients with acquired brain injury (ABI) (one-sample -test, ).

Group	Contrast	Brain regions	Side	BA	MNI space coordinates	Cluster extent	values
Activation
Healthy controls	Average activation	SPL	R	40	62 −44 48	174	20.0
		SMA	L	6/24	−34 2 42	52	13.1
		MFG	R	10/44/48	50 16 20	107	8.2
		MFG	L	46	−38 36 32	48	5.5
		IFG	R	44/48	34 20 36	518	8.2
		MTG	L	37	−48 −66 6	10	8.0
		Vermis IV-V	—	—	2 −46 −8	50	17.8
		Cerebellum, crus I	L	—	−44 −62 −28	22	7.0
		Thalamus	L	—	−8 −7 13	22	4.1
		Insula	R	48	42 15 −4	174	5.79
Healthy controls	Load activation	Calcarine cortex/ITG	R	17/37/19	14 −88 0	4114	29.3
		FFG/MOG	L	19	−46 −64 −16	2636	25.5
		MFG	R	46/47	44 56 −4	113	7.9
		IPL	L	7	−32 −56 50	79	11.1
		Insula	R	48	34 24 8	27	3.37
		Lingual gyrus	R	27	4 −32 −2	46	7.3
		Cerebellum, crus II	L	—	−6 −84 −36	66	9.2
ABI patients	Average activation	SPL	R	40	52 −48 40	71	4.3
		SMA	L/R	6	12 10 52	3946	10.5
		MFG	R	46	36 38 28	610	6.8
		IFG/putamen	R	47/48	40 26 6	2309	7.7
		MTG/STG	L/R	21/42/48	50 −48 4	381	5.4
		Vermis IV-V-VI/	—	—	0 −48 −10	2792	10.6
		Cerebellum, crus I	L		−36 −64 −32
		Thalamus	L	—	−18 −14 12	552	6.9
		Insula	L	48	−34 14 12	1262	6.0
ABI patients	Load activation	MOG	R	18/19	34 −86 10	2070	11.0
		MOG	L	18/19	−28 −92 8	1267	9.8
		IPL	L	7	−28 −56 48	214	6.0
		SMA	L	6	−6 8 50	1081	8.0
		Precentral gyrus	L	6	−44 −6 52	1661	7.2
		MFG	R	10/46	36 50 22	488	6.2
		Insula	R	47	36 14 10	24	4.4
		Cerebellum	L	—	−34 −76 −22	500	8.8
Deactivation
Healthy; controls	Average activation	MOG	L	19	−30 −80 28	860	8.1
		Precuneus	L	5	−8 −46 58	16	3.9
		Fusiform gyrus	L	37	−28 −34 −22	627	5.6
		Orbital IFG	L	47	−50 40 −2	120	5.0
Healthy; controls	Load activation	Precuneus	L/R	30	12 −46 46	2171	21.7
		SFG	L	10	−16 60 20	1229	27.8
		PCC	—	30	12 −52 16	256	15.9
		STG	R	48	44 −12 2	150	7.9
		MTG	L	21	−48 −68 20	298	6.5
		Insula	L	48	−36 −18 4	38	6.6
ABI patients	Average activation	SFG	L	10	−6 38 54	74	4.0
		Precuneus/MCC	L	7	−8 −60 54	6602	7.8
		STG/MTG	R	22	60 −4 10	206	4.2
		MOG	L	18	−30 −92 4	513	4.8
		MFG	L/R	10	8 60 −2	485	6.0
ABI patients	Load activation	STG	R	48	46 −12 6	2195	15.4
		Precuneus	L/R	30	−10 −42 58	1519	11.3
		Postcentral gyrus	L	48	−52 −10 18	667	11.1
		SFG	L/R	8/10/11	−20 16 −14	426	3.6
		PCC	—	—	−10 −40 38	261	7.5
		Insula	L	48	−26 12 −14	428	3.6

R = right; L = left; BA = Brodmann Area; FFG = fusiform gyrus; IFG = inferior frontal gyrus; IOG = inferior occipital gyrus; MOG = middle occipital gyrus; IPL = inferior parietal lobule; SPL = superior parietal lobule; MFG = middle frontal gyrus; MOG = middle occipital gyrus; ITG = inferior temporal gyrus; MTG = middle temporal gyrus; SMA = supplementary motor area; STG = superior temporal gyrus; MCC = middle cingulate cortex; PCC = posterior cingulate cortex.
, familywise error (FWE) corrected for multiple comparisons.