Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

<div>Changes in GABAergic tonic current in granule cells of the dentate gyrus during pregnancy and after delivery. (a) Representative traces (left) and all-point histogram (right) relative to GABAergic currents recorded in the whole-cell mode from granule cells of the dentate gyrus of hippocampal slices isolated from rats in estrus, at day P15 or P19, or at pp2. The effect of GABA (5 <i>μ</i>M) and bicuculline (30 <i>μ</i>M) is reported. Calibration: 50 pA, 2 min. (b, c) Bar graphs summarizing the changes in noise variance (b) and holding current (c) induced by the application of exogenous GABA in experiments similar to those shown in (a). Adapted from Sanna et al., 2009 [<a href="/journals/np/2015/170435/#B34">34</a>].</div>

Neural Plasticity

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Figure 2

Figure 2: Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function 