Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG

<div>Continuous treatment of MeCbl inhibited bilateral mechanical allodynia of CCD rats. Continuous treatment of MeCbl (1.25 mg/kg and 2.5 mg/kg) or Mannitol (2.5 mg/kg) was injected intraperitoneally from the 3rd postoperative day (black line segment). (a) Effects of MeCbl on bilateral mechanical paw withdrawal thresholds of CCD rats. (b) Effects of MeCbl on mechanical paw withdrawal thresholds of sham rats.</div>

Neural Plasticity

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Figure 2: Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG 

Figure 2 | Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG 