Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area

Table 1

Expression of p53-related genes in rat hippocampal CA1 area 30 min after tetanization.

Symbol	p53 transcriptional target genes		Vehicle		Nutlin-3
			Tetanization-induced fold change		Basal expression fold change		Tetanization-induced fold change
	Regulation	Reference	TSv/CSv	Paired -test, < 0.05	CSn/CSv	-test, < 0.05	TSn/CSn	Paired -test, < 0.05
Apaf1	+	[21, 22]	1,25		1,25		1,25
Apex1			1,11		1,29		0,98	ns
Atm			1,27		1,37		1,08
Bag1			1,13		1,30		1,01	ns
Bax	+	[23]	1,41		1,38		1,08	ns
Bbc3	+	[24]	0,93		1,33		0,87
Bcl2	−	[23]	0,71		0,92		0,94	ns
Bid	+	[25]	1,26		1,23		1,19
Birc5	−	[26]	1,22	ns	1,35		1,08	ns
Bnip3			1,13		1,27		1,08
Brca1	−	[27]	1,38		1,58		1,51	ns
Brca2			1,20		1,10		1,51
Btg2	+	[28]	1,47		1,41		1,11
Casp2			1,30		1,34		1,12
Casp9			1,14		1,28		1,02	ns
Ccnb1	−	[29]	1,03	ns	1,12		1,18
Ccne1			1,26		1,31		1,10	ns
Ccng1	+	[30]	1,31		1,35		1,16
Ccnh			1,18		1,25		1,11
Cdc25a	−	[31]	1,09	ns	1,06	ns	1,31
Cdc25c	−	[32]	1,17	ns	1,13		1,27
Cdk1	−	[33]	0,96	ns	1,01	ns	1,31
Cdk4			1,10		1,24		1,07
Cdkn1a	+	[34]	1,20		1,17		1,15	ns
Cdkn2a	−	[35]	1,06	ns	1,38		1,19	ns
Chek1	−	[27]	1,31		1,29		1,07	ns
Chek2	−	[36]	1,04	ns	1,22	ns	1,18
Cul9			1,20	ns	1,35		1,05	ns
Dapk1	+	[37]	1,34		1,41		0,90
Dnmt1	−	[38]	1,15	ns	1,19	ns	1,16
E2f1	−	[17]	1,34		1,22		1,28
E2f3			1,62		1,78		0,76
Egfr	+	[39]	1,39		1,33		1,29
Egr1	+	[40]	1,22		1,21		1,11
Ep300			1,17		1,22		1,02	ns
Ercc1			1,17		1,29		1,11
Fadd			1,39		1,57		0,83
Fas	+	[41, 42]	1,18	ns	1,14		1,23	ns
Faslg	+	[43]	1,19	ns	1,19		1,14
Foxo3			1,49		1,69		0,79
Gadd45a	+	[44]	1,26		1,41		0,96	ns
Hdac1			1,12	ns	1,24		1,10	ns
Hif1a			1,30		1,46		0,95	ns
Igf1r			1,08	ns	1,14		1,11
Il6	−	[45]	1,45		1,31		1,26
Jun			1,35		1,32		1,15
Kras			1,11	ns	1,22		1,07	ns
Mcl1			1,30		1,32		1,12
Mdm2	+	[46]	1,21		1,22		1,13	ns
Mdm4			1,16	ns	1,27		1,03	ns
Mlh1	+	[47]	1,16	ns	1,21		1,06	ns
Msh2	+	[48]	1,10	ns	1,11	ns	1,16
Myc	−	[49]	1,48		1,31		1,34
Nf1			1,54		1,25		1,37
Nfkb1			1,27		1,27		1,12
Pcna	+	[50]	1,33		1,28		1,29
Pmaip1	+	[51]	1,55		1,47		1,16
Ppm1d	+	[52]	1,11		1,23		1,10
Prc1	−	[53]	1,29	ns	1,28		1,20	ns
Prkca	−	[54]	1,30		0,92		1,58
Pten	+	[55]	1,47		1,46		0,92	ns
Pttg1	−	[56]	0,89		0,96	ns	0,69
Rb1	−	[57]	1,16	ns	1,30		1,01	ns
Rela			1,18		1,31		0,99	ns
RGD1566319	+	[58]	1,23	ns	1,32		1,04	ns
Rprm	+	[59]	0,74		0,95	ns	1,15
S100B	+	[60]	2,93		1,51		1,88
Sirt1			1,46		1,32		1,22
Stat1			1,24		1,36		1,00	ns
Tnf	+	[61]	1,28		1,25		1,13
Tp53	+	[40, 62]	1,00	ns	1,17	ns	1,07
Tp53bp2	−	[63]	1,11		1,13		1,06	ns
Tp63	+	[64]	1,17	ns	0,98	ns	1,39
Tp73	+	[40, 65, 66]	2,15		1,43		1,76
Xrcc4			1,03	ns	1,14		1,15
Xrcc5			1,35	ns	1,40		1,10	ns
Zmat3	+	[67]	0,99	ns	1,06	ns	1,22

TSv, CSv, TSn, CSn: test and control samples from experiments with vehicle (DMSO 0.1%) or nutlin-3 (20 M). Tetanization-induced fold changes (TSv/CSv and TSn/CSn) were expressed by taking the value of the corresponding control as one. Basal expression fold change (CSn/CSv) was expressed by taking average value of the group CSv as one. Italic marks symbols of the genes, which are regulated similarly by tetanization and nutlin, and effect of tetanization is occluded by nutlin. < 0.05 ( = 4), ns: not significant.