Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction

Figure 2

Effect of prolonged exercise on MI induced microglia and astrocyte morphological changes in the prefrontal cortex. 48 h MI induced significant changes in hypertrophic () and senescent () (dystrophic-like) microglia in the prefrontal cortex as compared to the sedentary group without MI ( and ). Both phenotypes were significantly reduced by the prolonged exercise ( and ) (a, b). 48 h MI did not modify the total (5.88 0.27) or reactive (2.36 0.05) astrocyte number in the prefrontal cortex, whereas exercise alone enhanced the resting/hypertrophic astrocyte ratio ( and ) (c, d). Data are presented as mean ± SEM. ANOVA followed by Tukey post hoc test was used for statistical analysis. Three animals were used for each experimental group. , and versus sedentary group; ^▪, ^▪▪, and ^▪▪▪ versus sedentary group with MI. Scale bars 100 and 25 μm for panoramic and inset image, respectively.

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