Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction

Figure 3

Effect of prolonged exercise on MI induced microglia and astrocyte morphological changes in the hippocampus. 48 h MI induced significant changes in hypertrophic and senescent (dystrophic-like) microglia in the hippocampus as compared to the sedentary group without MI ( and ). Both phenotypes were significantly reduced by the prolonged exercise ( and ) (a, b). 48 h MI did not modify the total or reactive astrocyte number in the hippocampus ( and ) (c, d). Data are presented as mean ± SEM. ANOVA followed by Tukey post hoc test was used for statistical analysis. Three animals were used for each experimental group. , and versus sedentary group; ^▪, ^▪▪, and ^▪▪▪ versus sedentary group with MI. Scale bars 100 and 25 μm for panoramic and inset image, respectively. Scale bars 100 and 25 μm for panoramic and inset image, respectively.

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