Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction

Figure 4

Effect of prolonged exercise on MI induced microglia and astrocyte morphological changes in the thalamus. 48 h MI induced significant changes in the senescent () (dystrophic-like) microglia in the thalamus as compared to the sedentary group without MI (). Both phenotypes were significantly reduced by the prolonged exercise (a, b). 48 h MI induced increased number of reactive astrocytes () as compared to the sedentary group without MI (). Exercise significantly reduced the number of reactive astrocytes in MI animals () (c, d). Data are presented as mean ± SEM. ANOVA followed by Tukey post hoc test was used for statistical analysis. Four animals were used for each experimental group. , and versus sedentary group; ^▪, ^▪▪, and ^▪▪▪ versus sedentary group with MI. Scale bars 100 and 25 μm for panoramic and inset image, respectively. Scale bars 100 and 25 μm for panoramic and inset image, respectively.

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