Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic 7 Nicotinic Receptor Drugs

Figure 4

Treatment with the cholinergic 7 nicotinic receptor agonist JN403 decreases the number of 7 nicotinic receptor-expressing astrocytes in the dentate gyrus. (a) The number of 7 nicotinic receptor/glial fibrillary acidic protein-positive (nAChR+/GFAP+) cells and the number of 7 nAChR-negative/GFAP+ cells in the dentate gyrus of Tg2576 mice that received SHAM (vehicle) transplants and saline (SHAM + SAL) or hNSC transplants and saline (hNSC + SAL), JN403 (hNSC + JN), or (+)-phenserine (hNSC + PHEN). (b) Representative images of 7 nAChR+/GFAP+ cells (black) and 7 nAChR-negative/GFAP+ cells (brown) in hNSC + SAL and hNSC + JN mice. (c) Representative image of 7 nAChR+/GFAP+ cells (black) in the needle track after hippocampal injection. compared to SHAM + SAL. The data are expressed as means ± SEM.

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