α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

Figure 5

Glutamine synthetase expression level in astrocyte monoculture. Astrocytes were separately treated with 1 μM oxaliplatin, 10 μM PNU or coincubated with oxaliplatin and PNU for 48 h. Densitometric analysis (b) and representative western blot (a) are shown. GAPDH normalization was performed for each sample. Values are expressed as the mean ± S.E.M. of 3 experiments. One-way ANOVA was performed followed by a Bonferroni significant difference procedure. versus control.

(a)

(b)