Review Article
The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder
Table 4
Summary of findings from studies examining cytokine alterations in the central nerve system of patients with bipolar disorder.
| Outcome | studies | BD vs. controls | References |
| NR-1 (mRNA and Protein) | 1 | + | [52] | NR-2A (mRNA and Protein) | 1 | + | [52] | IL-1β (mRNA and Protein) | 3 | + | [50, 52, 53] | IL-1R (mRNA and Protein) | 1 | + | [52] | MyD88 (mRNA and Protein) | 1 | + | [52] | GFAP (mRNA and Protein) | 2 | + | [50, 52] | iNOS (mRNA and Protein) | 1 | + | [52] | TNFα | 2 | + | [50, 52] | IL-6 | 1 | − | [53] | tmTNFa | 1 | + (at BA 24) | [50] | Astrocyte | 1 | + | [52] | Microglia markers | 1 | + | [52] | TNFR2 | 1 | − | [50] |
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