Age-Related Alterations in the Expression of Genes and Synaptic Plasticity Associated with Nitric Oxide Signaling in the Mouse Dorsal Striatum

Table 2

The magnitude and occurrence of changes in corticostriatal field responses induced by high-frequency stimulation (HFS) in striatal slices from the brain of four age groups of mice. The magnitude of LTD/LTP was measured as the mean relative change in field response amplitude within 45–60 min after HFS.

Post-HFS changes in responses	Age groups
	I	II	III	IV
Long-term depression,  LTD	71 ± 2%; (36%)	48 ± 7%; (38%)	71 ± 1%; (18%)	62 ± 5%; (30%)
Long-term potentiation, LTP	126 ± 2%; (36%)	171 ± 9%; (54%)	165 ± 9%; (55%)	136 ± 2%; (48%)
No long-term changes; NLTC	101 ± 2%; (28%)	100 ± 2%; (8%)	94 ± 1%; (27%)	97 ± 2%; (22%)

indicates the number of slices with its percent ratio to the total number of slices in a group in parentheses. Asterisks indicate significant difference in the magnitude of LTD/LTP with respect to group I values , , one-way ANOVA with Dunnett’s posttest and unpaired -test).