Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine

Figure 2

Ceramide subspecies are differentially regulated in the peri-infarct cortex. (a) Total ceramide, ceramide 16:0, 18:0, and 24:0 in the time course after photothrombotic stroke compared to sham. Asterisks for values as well as ceramide 18:1 and 24:1 are not shown (see Section 3). (b) Ratios for ceramide 16:0/ceramide 24:0 + 24:1. Data are presented as means ± SD. Differences between sham and PT group were analyzed using Student’s unpaired two-tailed -test.; ; n.s., nonsignificant; = 8–10.

(a)

(b)