Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses

Figure 1

(a) Graph showing the significant relationship between the PP ratio and release probability using data from previous variance-mean analyses (see Section 2). (b) Analysis of the estimated available vesicle pool from the depression of connections. The inset shows two synapses that were depressed from different initial EPSP amplitudes. (c) Traces showing different forms of activity-dependent plasticity. Metaplasticity (1) is defined as reduced depression or increased facilitation from an increased initial EPSP amplitude; release probability-dependent facilitation (2; thick line) as facilitation from a reduced initial EPSP amplitude; and release probability-dependent depression (3) as depression from a larger initial EPSP amplitudes.

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