Complex Inflammation mRNA-Related Response in ALS Is Region Dependent

Table 1

Summary of clinical and pathological data in the present series.

Case	Pathology	Sex	Age	P-M	RIN FC	RIN SC
1	0	M	43	5 h 55 m	8.1	6.5
2	0	M	47	4 h 55 m	7.8
3	0	M	46	15 h	7.7	6
4	0	F	71	8 h 30 m	7.4	6
5	0	M	52	3 h	8.2
6	0	M	64	8 h 30 m	7.7
7	0	M	67	5 h	7.4
8	0	F	49	7 h	8.2
9	0	F	75	3 h	7.7
10	0	F	64	5 h		7.1
11	AD II	F	86	4 h 15 m
12	AD I	F	79	3 h 35 m
13	AD I	F	79	6 h 25 m		6.9
14	AD II	F	77	3 h 15 m
15	AD II	F	76	5 h 45 m
16	AD I	F	59	11 h 20 m		6.9
17	AD I	M	76	6 h 30 m		6.8
18	AD I	M	56	7 h 10 m		6.3
19	AD II	M	66	4 h 55 m		6.4
20	ALS/ADI	F	76	13 h		6.6
21	ALS	F	59	14 h 15 m	6.5
22	ALS	M	54	4 h 50 m	7.7
23	ALS	M	70	3 h	7.2	7.2
24	ALS	M	56	10 h 50 m		7.4
25	ALS	M	77	4 h 30 m	8	7.9
26	ALS/AD II	F	75	4 h 5 m		7
27	ALS	F	57	10 h	7.4	6.7
28	ALS	F	56	3 h 45 m	8.3	8.3
29	ALS/AD II	M	57	4 h		6.5
30	ALS/AD II	F	79	2 h 10 m		7.4
31	ALS	M	64	16 h 30 m	7.4	7
32	ALS	M	59	3 h 15 m	7.8	7.5
33	ALS	F	63	13 h 50 m	7.4	6.9

Thirty-three cases are analyzed corresponding to 19 controls and 14 amyotrophic lateral sclerosis (ALS) cases. Some ALS cases have concomitant AD-related pathology at stages I-II of Braak (AD I-II), and for this reason some control cases with similar stages of AD-related pathology are included in the study of the anterior lumbar spinal cord. However, only cases without AD-related pathology are selected for study in the frontal cortex area 8 (see text). M: male; F: female; P-M: postmortem delay (hours, minutes); FC: frontal cortex area 8; SC: anterior lumbar spinal cord; RIN: RNA integrity number.