Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Alter the Gut-Brain Communication

Figure 1

The RYGB operation dramatically reduced the number of retrogradely labeled (FB) afferent ((A), (D) in NG) and efferent ((A), (G) in DMV) neurons innervating the stomach. We found no significant difference in the number of afferent and efferent FB-labeled neurons innervating the stomach following sham ((A), (B) and (A), (E), resp.) or VSG ((A), (C) and (A), (F), resp.) surgery. (B)–(D) Representative sections of NG: nodose ganglion showing FB-labeled neurons. (E)–(G) Representative sections of DMV: dorsal motor nucleus of the vagus showing FB-labeled neurons. All data are expressed as average ± SEM; ; scale bar = 200 μm.