Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum

Figure 10

Modulation of NMDA-induced depression of neuronal and glial currents. (a) Mean EPSC₁ amplitude following incubation with 30 μM NMDA and 10 μM glycine, either alone or in the presence of the stated inhibitors (L-NAME, 100 μM; ODQ, 10 μM; SR141716, 5 μM; CPG 52432, 10 μM). Control data from untreated cells stimulated for the same period are provided for reference. Data are mean ± s.e.m. from 5–7 cells. Statistical significance was tested by Dunnett’s multiple comparisons test following one-way ANOVA. (b) Mean ESC₁ amplitude following incubation with 30 μM NMDA and 10 μM glycine, either alone or in the presence of the stated inhibitors (L-NAME, 100 μM; ODQ, 10 μM; SR141716, 5 μM; CPG 52432, 10 μM). Control data are provided for reference. Data are mean ± s.e.m. from 5–9 cells. Statistical significance was tested by Dunnett’s multiple comparisons test following one-way ANOVA. ; .

(a) Purkinje neuron

(b) Bergmann glia