Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

Figure 4

The effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. (A1, B1) Schematic representation of the experimental protocol is presented on the top of each panel. (A2) Animals were trained in the IA and exposed to an OF 11 h later. Shortly after exploration, rats were CA1 infused with SCH 23390 (1.5 μg/1 μL per side) or veh. Two other groups of rats were infused with veh or SCH in the absence of OF. Test was performed 7 days after training. (B2) Animals were trained in the IA and 8 h after training they were CA1 infused with antisense (ASO) or missense (MSO) oligonucleotide of arc. 3 h later they were exposed to an OF. Two other groups of rats were infused with MSO or ASO in the absence of OF. Test was performed 7 days after training. Data are presented as mean ± SEM.

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