Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury
Table 11
Latency and amplitude measured by evoked potentials of the upper limbs in patients with cervical SCI who showed response of MEP over 1 year after hNSPC transplantation.
Patient
Before
2 months
6 months
1 year
Right
Left
Right
Left
Right
Left
Right
Left
Biceps brachii muscle (latency)
6
0.00
0.00
0.00
0.00
14.49
14.31
15.99
17.37
9
0.00
0.00
13.01
13.27
14.57
14.40
14.50
14.60
10
0.00
0.00
0.00
0.00
12.39
0.00
12.16
0.00
Biceps brachii muscle (amplitude)
1
0.00
0.00
0.00
0.00
0.79
0.87
0.69
0.61
2
0.00
0.00
0.00
0.00
0.22
0.00
0.62
0.00
6
0.00
0.00
0.00
0.00
0.75
1.25
0.88
0.53
9
0.00
0.00
0.36
0.20
0.65
0.40
0.84
0.54
10
0.00
0.00
0.00
0.00
1.37
0.00
1.66
0.00
12
0.00
0.00
0.00
0.00
0.00
0.00
0.51
0.42
14
0.55
0.00
0.62
0.38
2.14
1.39
1.07
0.66
16
0.00
0.00
0.85
0.76
0.91
2.49
1.57
1.00
17
0.00
0.00
0.82
0.84
0.93
1.24
1.21
1.58
Abductor pollicis brevis muscle (latency)
3
0.00
0.00
24.85
0.00
25.95
0.00
28.59
0.00
11
0.00
0.00
0.00
0.00
0.00
30.06
0.00
0.00
Abductor pollicis brevis muscle (amplitude)
3
0.00
0.00
0.39
0.00
0.07
0.00
0.18
0.00
11
0.00
0.00
0.00
1.06
0.00
0.00
0.00
0.00
Right side, left side, ms, microvolts, and the patient showed recovery of MEPs at 2- or 6-month follow-up times. However, the peripheral response to transcranial stimulation disappeared at 1 year after transplantation.
