Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury
Table 12
Changes in spinal MRI findings in patients with cervical SCI before and 1 year after hNSPC transplantation.
Patient
Before transplantation
1 year after transplantation
Types
Location
Lesion length
Types
Location
Lesion length
1
I
C2.3–C7.1
81.2 mm
B, C
C4.1–C5.2
29.3 mm
2
I
C2.3–C4.2
33.5 mm
A, B
C3.2–C4.1
12.3 mm
3
III
C5.1–C7.1
30.5 mm
B
C6.2–C6.3
10.3 mm
4
IV
C3.1–C7.2
70.3 mm
B
C5.2–C7.2
32.9 mm
5
IV
C2.1–C7.2
99.6 mm
B
C5.1–C6.3
37.5 mm
6
N/A
C3.3–C5.3
34.6 mm
B
C3.3–C5.2
33.8 mm
7
II
C3.3–C7.1
62.2 mm
B
C5.1–C6.1
24.2 mm
8
IV
C2.1–C7.3
57.1 mm
B
C5.1–C6.1
25.4 mm
9
N/A
C3.3–C4.1
13.8 mm
B
C3.3–C4.1
12.6 mm
10
III
C2.3–C5.3
59.9 mm
C
C3.2–C4.1
13.5 mm
11
IV
C4.3–T1.3
76.7 mm
B, C
C6.1–T1.2
42.9 mm
12
I
C2.1–C5.3
70.0 mm
B
C2.3–C4.3
43.0 mm
13
IV
C3.1–T2.1
101.6 mm
B
C5.2–C6.2
19.3 mm
14
III
C4.2–T1.1
58.4 mm
B
C5.2–C7.1
36.0 mm
15
IV
C2.3–C7.1
89.8 mm
A, B
C3.2–C6.2
59.4 mm
16
I
C2.3–C6.2
67.6 mm
A, B
C4.1–C6.1
41.8 mm
17
III
C4.2–T1.1
84.0 mm
B
C5.1–C6.3
33.7 mm
18
III
C5.2–T1.1
42.3 mm
C
C7.1–C7.2
9.0 mm
19
III
C6.1–T1.2
40.7 mm
B
C7.2
6.9 mm
Types of acute SCI pattern: Type I: hemorrhage, Type II: edema, Type III: mixed or contusion, and Type IV: compression. Types of subacute and chronic SCI pattern: type A: atrophy, type B: myelomalacia, type C: cyst, and type D; syrinx. Spine MRI studies were not available in the acute phase of SCI; however, MRI scan showed myelomalacia before hNSPC transplantation.
