The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells

Figure 1

aNPCs from MMP-1 tg animals release MMP-1 and have an increased proliferation rate. (a) Supernatants from tg cultures express hMMP-1 as detected by ELISA. (b) Time course analysis of proliferation for WT and MMP-1 tg-derived aNPC. Cells from tg animals display an increased proliferation rate, compared to WT-derived aNPC (b). Data are the mean ± SD from four replicate wells and are representative of an experiment performed with different NPC preparations on three separate occasions (; versus WT).

(a)

(b)