Multiscale Modeling Indicates That Temperature Dependent [Ca²⁺]_i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity

Figure 3

Dependence of Ca²⁺ signals on the pump strength. The temperature dependent activity of SERCA leads to higher pump rates for higher temperatures. This influences the Ca²⁺ signals as shown by the number of open channels (a) and the corresponding Ca²⁺ concentrations (b). For the two smallest strengths the simulations ended before the shown real time of 800 s caused by run time restrictions on the compute cluster.