Multiscale Modeling Indicates That Temperature Dependent [Ca²⁺]_i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity

Figure 7

SERCA pump activity depends linearly on the temperature as shown independently by our model inference (line) and by experimental data from tuna species (data points from [26], Figure 2(b)). For the experimental data points the pump strength is set to 100% at 30°C and used for normalisation for the lower temperatures leading to relative activity values shown on the left vertical axis. As a comparison the inference from our simulation (4) is shown by the straight line with the absolute values given on the right vertical axis.