Multiscale Modeling Indicates That Temperature Dependent [Ca²⁺]_i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity

Table 2

Physiologic parameters of the in silico cell used for the rate equation simulations.

Additional flux definitions of the full rate equation model
Sodium-Ca^2+ exchanger mediated flux
Mitochondrial unitransporter mediated flux
Effective mitochondrial flux
Leak flux through ER membrane
Influx from external space
PMCA mediated flux
Parameter values for the rate equation calcium model
= 0.03 ms^−1	= 0.5 μM	= 0.9 μM	= 1.3 μM
= 0.2 μM	= 0.06 μM ms^−1	= 10 μM ms^−1	= 0.6 μM
= 1 μM	= 10 μM	= 0.2 μM ms^−1	= 1 μM
=  ms^−1	=  ms^−1	=  ms^−1	= 0.01 μM ms^−1
= 0.7 μM	= 0.4 μM		= 0.5
=  μM ms^−1