A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain

Figure 3

Development of mechanical hypersensitivity and thermal hyperalgesia following chronic compression of DRG (CCD) in rats. (a-b) Mechanical hypersensitivity developed in CCD rats but not in sham controls for both ipsilateral (a) and contralateral hindpaws (b). Note that paw withdrawal mechanical threshold (PWMT) to von Frey hairs decreased dramatically from the 1st day following chronic compression of L5 DRG (; ). (c-d) Thermal hyperalgesia was observed by measuring paw withdrawal thermal latency (PWTL) to radiant heat in CCD rats and sham controls for both ipsilateral (c) and contralateral hindpaws (d). Note that PWTL significantly decreased in CCD rats (; ) but not in sham group (; ) with a similar time course with mechanical hypersensitivity. All data are expressed as mean ± S.E.M.

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