A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain

Figure 4

(a, b) Intraperitoneal (i.p.) administration of SANR (54, 180, and 540 μmol/kg body weight) attenuated mechanical hypersensitivity (a) and thermal hyperalgesia (c) induced by chronic compression of lumbar DRG in a dose-dependent manner (). Concentration-response curves of SANR at 7 h after drug delivery on mechanical hypersensitivity (b) and thermal hyperalgesia (d) are shown, respectively. (e, f) Motor coordination was not altered by systemic SANR (180 μmol/kg, i.p.). Quantitative analysis showing that i.p. SANR did not affect the latency (e) and speed (f) for rats falling from the accelerating rod, as compared to vehicle group ( for each group, ). All data are expressed as mean ± S.E.M.

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