Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

Figure 3

Gene transcription profiles in 5XFAD mice. RNA extracted from the hippocampus of control and 5XFAD mice was used for microarray analysis. A selected number of candidates which exhibited altered expression profile in microarray analysis were further validated using quantitative real-time PCR (qPCR). Normalized ΔΔCT (log scale) for Cacna2d1, Kcnma1, -loop, Prkcb, Plcb1, Scn8a, Plcd4, and Casp8 is depicted. Note that a minor decrease in Plcb1 transcript levels turned out to exist, but a clear increase in Plcd4 in 5XFAD mice.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)