Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

Figure 4

Time-frequency analysis of theta activity in control and 5XFAD mice. (a) Color-coded time-frequency plot of extracted theta segments from EEG data. These segments were clued together (13 minutes in total) for a better demonstration of the oscillatory activity. The -axis represents the frequency range of 4–12 Hz. (b) Mean theta frequency (Hz) calculated for the hippocampal theta-alpha band (4–12 Hz). Note that (a) and (b) display specific episodes of consistent, high amplitude, low frequency EEG activity that was proven to be related to behavioral aspects such as grooming, scratching, or eating based on video analysis. A specific algorithm was defined to automatically detect and eliminate these episodes from further evaluation (black bars, (b)).