Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

Figure 6

Characteristics of theta duration in control and 5XFAD mice. The theta-alpha band was analyzed using a time-frequency approach. Behavioral artefacts were removed using an algorithm as described above. Theta-segments (10 s) were summed to determine theta duration (min/h). Theta duration was calculated for both genotypes for the total observation period (a) and the light (b) and dark (c) phases, respectively. Total and phase-specific analysis was also done for nonmotor activity ((d)–(f)) and motor activity (not shown). Mean values suggest an increase in theta duration in 5XFAD mice, particularly during the dark phase ((c), (f)).

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