Limited Effects of an eIF2α^S51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease

Figure 3

EEG recordings revealed nonconvulsive seizure activity in the motor cortex of animals carrying the 5xFAD transgenes and/or the allele. Radiotelemetric recordings from the primary motor cortex (M1) of wild-type, 5xFAD, 5xFAD;, and mice (WT, mice; 5xFAD, mice; 5xFAD;, mice; , mice). Wild-type mice did not exhibit seizure activity, whereas all other genotypes showed episodes of spike, polyspike, and spike-wave activity. Shown are example traces, as well as a quantification of the number of seizure episodes and the number of spikes, respectively. Bar graphs show mean ± SEM.