Genotype-Dependent Difference in 5-HT_2C Receptor-Induced Hypolocomotion: Comparison with 5-HT_2A Receptor Functional Activity

Table 1

Behavior of CBA mice treated with MK-212 and saline in the open field test.

	Time spent in center, %	Amount of rearing	Amount of grooming	Time of grooming
Saline	10.3 ± 4.3	4.8 ± 2.0	0.8 ± 0.3	4.1 ± 2.7
0.1	7.2 ± 3.5	2.5 ± 1.2	1.3 ± 0.4	2.1 ± 0.8
1.0	5.9 ± 1.9		1.0 ± 0.4	5.1 ± 2.2
2.0	5.5 ± 2.6		0.3 ± 0.2	1.1 ± 0.7
4.0			0.6 ± 0.3	2.2 ± 1.2

Data are presented as the mean ± SEM ( per group). Time spent in center is presented as the percentage to total time of test. Statistically significant differences: , versus saline group.