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Neural Plasticity
Volume 2015, Article ID 858251, 7 pages
http://dx.doi.org/10.1155/2015/858251
Research Article

Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression

1New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USA
2National Institute of Mental Health, National Institutes of Health, Experimental Therapeutics and Pathophysiology Branch, 10 Center Drive, Building 10/CRC, Bethesda, MD 20892, USA
3Massachusetts General Hospital, Depression Clinical & Research Program, 1 Bowdoin Square, 6th Floor, Boston, MA 02114, USA
4Department of Psychiatry & Psychological Services, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

Received 3 February 2015; Revised 21 March 2015; Accepted 13 May 2015

Academic Editor: Lin Xu

Copyright © 2015 Annie J. Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Baldessarini, E. Vieta, J. R. Calabrese, M. Tohen, and C. L. Bowden, “Bipolar depression: overview and commentary,” Harvard Review of Psychiatry, vol. 18, no. 3, pp. 143–157, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Tirupati and L.-E. Chua, “Obesity and metabolic syndrome in a psychiatric rehabilitation service,” Australian and New Zealand Journal of Psychiatry, vol. 41, no. 7, pp. 606–610, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Maayan and C. U. Correll, “Weight gain and metabolic risks associated with antipsychotic medications in children and adolescents,” Journal of Child and Adolescent Psychopharmacology, vol. 21, no. 6, pp. 517–535, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Diazgranados, L. Ibrahim, N. E. Brutsche et al., “A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression,” Archives of General Psychiatry, vol. 67, no. 8, pp. 793–802, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. C. A. Zarate Jr., N. E. Brutsche, L. Ibrahim et al., “Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial,” Biological Psychiatry, vol. 71, no. 11, pp. 939–946, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. K. Rybakowski, A. Permoda-Osip, M. Skibinska, R. Adamski, and A. Bartkowska-Sniatkowska, “Single ketamine infusion in bipolar depression resistant to antidepressants: are neurotrophins involved?” Human Psychopharmacology, vol. 28, no. 1, pp. 87–90, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. J. Niciu, D. A. Luckenbaugh, D. F. Ionescu, D. C. Mathews, E. M. Richards, and C. A. Zarate Jr., “Subanesthetic dose ketamine does not induce an affective switch in three independent samples of treatment-resistant major depression,” Biological Psychiatry, vol. 74, no. 10, pp. e23–e24, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. E.-M. Hur and F.-Q. Zhou, “GSK3 signalling in neural development,” Nature Reviews Neuroscience, vol. 11, no. 8, pp. 539–551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. R. S. Jope, “Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes,” Trends in Pharmacological Sciences, vol. 24, no. 9, pp. 441–443, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. P. S. Klein and D. A. Melton, “A molecular mechanism for the effect of lithium on development,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 16, pp. 8455–8459, 1996. View at Google Scholar
  11. V. Stambolic, L. Ruel, and J. R. Woodgett, “Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells,” Current Biology, vol. 6, no. 12, pp. 1664–1668, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. W. J. Ryves and A. J. Harwood, “Lithium inhibits glycogen synthase kinase-3 by competition for magnesium,” Biochemical and Biophysical Research Communications, vol. 280, no. 3, pp. 720–725, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Beurel, L. Song, and R. S. Jope, “Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice,” Molecular Psychiatry, vol. 16, no. 11, pp. 1068–1070, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Ghasemi, M. Raza, and A. R. Dehpour, “NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test,” Journal of Psychopharmacology, vol. 24, no. 4, pp. 585–594, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. R.-J. Liu, M. Fuchikami, J. M. Dwyer, A. E. Lepack, R. S. Duman, and G. K. Aghajanian, “GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine,” Neuropsychopharmacology, vol. 38, no. 11, pp. 2268–2277, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Atmaca, “Valproate and neuroprotective effects for bipolar disorder,” International Review of Psychiatry, vol. 21, no. 4, pp. 410–413, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. H. A. Sackeim, “The definition and meaning of treatment-resistant depression,” Journal of Clinical Psychiatry, vol. 62, supplement 16, pp. 10–17, 2001. View at Google Scholar · View at Scopus
  18. M. J. Niciu, D. A. Luckenbaugh, D. F. Ionescu et al., “Clinical predictors of ketamine response in treatment-resistant major depression,” Journal of Clinical Psychiatry, vol. 75, no. 5, pp. e417–e423, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. D. A. Luckenbaugh, M. J. Niciu, D. F. Ionescu et al., “Do the dissociative side effects of ketamine mediate its antidepressant effects?” Journal of Affective Disorders, vol. 159, pp. 56–61, 2014. View at Publisher · View at Google Scholar
  20. N. Lundin, M. Niciu, D. Luckenbaugh et al., “Baseline vitamin B12 and folate levels do not predict improvement in depression after a single infusion of ketamine,” Pharmacopsychiatry, vol. 47, no. 4-5, pp. 141–144, 2014. View at Publisher · View at Google Scholar
  21. R. Vadnal and R. Parthasarathy, “Myo-inositol monophosphatase: diverse effects of lithium, carbamazepine, and valproate,” Neuropsychopharmacology, vol. 12, no. 4, pp. 277–285, 1995. View at Publisher · View at Google Scholar · View at Scopus
  22. H. K. Manji, R. Etcheberrigaray, G. Chen, and J. L. Olds, “Lithium decreases membrane-associated protein kinase C in hippocampus: Selectivity for the α isozyme,” Journal of Neurochemistry, vol. 61, no. 6, pp. 2303–2310, 1993. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Kirshenboim, B. Plotkin, S. B. Shlomo, O. Kaidanovich-Beilin, and H. Eldar-Finkelman, “Lithium-mediated phosphorylation of glycogen synthase kinase-3β involves PI3 kinase-dependent activation of protein kinase C-α,” Journal of Molecular Neuroscience, vol. 24, no. 2, pp. 237–245, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Shim and R. C. Smart, “Lithium stabilizes the CCAAT/enhancer-binding protein a (C/EBPα) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibition of proteasomal activity,” The Journal of Biological Chemistry, vol. 278, no. 22, pp. 19674–19681, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. S. M. Stahl, “Anticonvulsants as mood stabilizers and adjuncts to antipsychotics: valproate, lamotrigine, carbamazepine, and oxcarbazepine and actions at voltage-gated sodium channels,” Journal of Clinical Psychiatry, vol. 65, no. 6, pp. 738–739, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. H. M. Emrich, D. von Zerssen, W. Kissling, and H. J. Möller, “On a possible role of GABA in mania. Therapeutic efficacy of sodium valproate,” Advances in Biochemical Psychopharmacology, vol. 26, pp. 287–296, 1981. View at Google Scholar · View at Scopus
  27. G. Chen, L.-D. Huang, Y.-M. Jiang, and H. K. Manji, “The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3,” Journal of Neurochemistry, vol. 72, no. 3, pp. 1327–1330, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. C.-T. Chiu, Z. Wang, J. G. Hunsberger, and D.-M. Chuang, “Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder,” Pharmacological Reviews, vol. 65, no. 1, pp. 105–142, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Leng, M. H. Liang, M. Ren, Z. Marinova, P. Leeds, and D.-M. Chuang, “Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: Roles of glycogen synthase kinase-3 inhibition,” The Journal of Neuroscience, vol. 28, no. 10, pp. 2576–2588, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. A. Quiroz, N. A. Gray, T. Kato, and H. K. Manji, “Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder,” Neuropsychopharmacology, vol. 33, no. 11, pp. 2551–2565, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. M. J. Kempton, J. R. Geddes, U. Ettinger, S. C. R. Williams, and P. M. Grasby, “Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder,” Archives of General Psychiatry, vol. 65, no. 9, pp. 1017–1032, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. R. MacHado-Vieira, M. G. Soeiro-De-Souza, E. M. Richards, A. L. Teixeira, and C. A. Zarate Jr., “Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: developing treatments using an integrated translational approach,” World Journal of Biological Psychiatry, vol. 15, no. 2, pp. 84–95, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Villaseñor, A. Ramamoorthy, M. Silva dos Santos et al., “A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks,” British Journal of Pharmacology, vol. 171, no. 8, pp. 2230–2242, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Li, B. Lee, R.-J. Liu et al., “mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists,” Science, vol. 329, no. 5994, pp. 959–964, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. A. E. Autry, M. Adachi, E. Nosyreva et al., “NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses,” Nature, vol. 475, no. 7354, pp. 91–96, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. A. B. M. Cunha, B. N. Frey, A. C. Andreazza et al., “Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes,” Neuroscience Letters, vol. 398, no. 3, pp. 215–219, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. J. F. Tramontina, A. C. Andreazza, M. Kauer-Sant'Anna et al., “Brain-derived neurotrophic factor serum levels before and after treatment for acute mania,” Neuroscience Letters, vol. 452, no. 2, pp. 111–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. C. A. Zarate Jr., N. Brutsche, G. Laje et al., “Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression,” Biological Psychiatry, vol. 72, no. 4, pp. 331–338, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. J. R. Calabrese, M. D. Shelton, C. L. Bowden et al., “Bipolar rapid cycling: focus on depression as its hallmark,” Journal of Clinical Psychiatry, vol. 62, supplement 14, pp. 34–41, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. M. E. Thase, “Bipolar disorder maintenance treatment: monitoring effectiveness and safety,” The Journal of Clinical Psychiatry, vol. 73, no. 4, article e15, 2012. View at Publisher · View at Google Scholar · View at Scopus