Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat

Figure 2

Representative images of GABA-ir and NeuN-ir cells in laminae I–III of the spinal dorsal horn. Photomicrographs of the areas of the squares are presented in (a), which cover the lateral portions of laminae I–III, and are shown in (b). The GABA-ir cells in the ipsilateral laminae I–III appear to be distributed less densely for 1-week and 8-week post-CCD groups than for sham-operated and 18-week post-CCD groups, with no density difference in the contralateral laminae among the four groups. The NeuN-ir cells show no differences in density between both sides of the dorsal horn laminae as well as among all four groups. Typical GABA-ir and NeuN-ir cells are seen in insets at the lower right of each image (indicated by arrows).

(a)

(b)